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Dr. Cannabis

Glossary

Titration

Increasing a dose gradually until you find the smallest amount that works. The core safety practice in cannabis dosing.

Published guidance converges on a starting oral THC dose of roughly 1 to 2.5 mg, with increases of 1 to 2.5 mg every two to three days.

The reason to go slowly is that THC has a biphasic dose-response: past a certain point, more produces worse results, not better. Titration finds the point before that.

Also written as: titrate, start low go slow.

Related terms

Sources

  1. Bhaskar A, Bell A, Boivin M, et al. Consensus recommendations on dosing and administration of medical cannabis to treat chronic pain: results of a modified Delphi process. Journal of Cannabis Research. 2021;3(1):22.(DOI 10.1186/s42238-021-00073-1 / PMID 34215346)Accessed 2026-08-15.
  2. MacCallum CA, Russo EB. Practical considerations in medical cannabis administration and dosing. European Journal of Internal Medicine. 2018;49:12-19.Accessed 2026-08-15.
  3. Health Canada. Cannabis: Lower your risks. Modified 2019-06-14.Accessed 2026-08-15.